What Melanotan II is
Melanotan II (MT2) is a synthetic cyclic heptapeptide built on the central sequence of α-melanocyte-stimulating hormone. A lactam bridge joins the side chain of aspartate 2 to the side chain of lysine 7, closing a six-residue ring around the His-D-Phe-Arg-Trp core that melanocortin receptors recognise. The ring, the D-phenylalanine and an N-terminal acetyl-norleucine make MT2 compact and resistant to peptidases, and it binds several melanocortin receptor subtypes (MC1R, MC3R, MC4R and MC5R) rather than one.
MT2 Labs supplies Melanotan II as a lyophilized powder in 10 mg vials. Every lot is tested by an independent laboratory for HPLC-UV purity, LC-MS identity and net content, and the certificate is published here before sale through Klow.bio.
MT2 is a cyclic peptide and a different compound from Melanotan I (MT1), a longer linear analog. Their formulas and molecular weights differ (1024.18 vs 1646.85 g/mol).
Structure
MT2 is Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2. The cyclizing amide bond between Asp2 and Lys7 side chains removes one water from the linear sequence, which is reflected in the formula. The N-terminus is acetylated and the C-terminus amidated, so the molecule has no free terminal charges; arginine is its main basic group.
complete MT2 specifications.
Storage and handling
Store sealed, dry and protected from light at the temperature stated on the vial label. Allow a cold vial to reach room temperature before opening. Lyophilized material absorbs moisture from the air, and absorbed moisture restarts the reactions that drying slows, so keep vials sealed until needed. Storage and stability guide.